Perineuronal nets (PNNs) are chondroitin sulphate proteoglycan-containing structures on the neuronal surface that have been implicated in the control of neuroplasticity and memory. Age-related reduction of chondroitin 6-sulphates (C6S) leads to PNNs becoming more inhibitory. Here, we investigated whether manipulation of the chondroitin sulphate (CS) composition of the PNNs could restore neuroplasticity and alleviate memory deficits in aged mice.

Meet your new hero! My friend Staci, or Spezzy as she's known around the Nerd Fitness community, has one of the best transformations I've ever seen: Working a sedentary desk job, Staci slowly packed on weight and ate like a typical unhealthy American. She also smoked a pack of cigarettes a day.

I ride and continue to ride for a lot of the same reasons as you with the added benefit of it helping to keep the clouds at bay. If your reading this from an outsiders point of view, understand that the issues mentioned in this article aren't a choice, a weakness or a minor challenge that could be easily surmounted by someone with a stronger constitution.

Ladies, meet your new hero. Men, prepare to be humbled. My friend Staci, or Spezzy as she's known around the Nerd Fitness community, has one of the best success stories I've ever seen. For the women out there who are scared about "getting too bulky when lifting weights," this article is for you.