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Chondroitin 6-sulphate is required for neuroplasticity and memory in ageing


Science & Medicine Blogs Jul 16, 2021 by Molecular Psychiatry


Perineuronal nets (PNNs) are chondroitin sulphate proteoglycan-containing structures on the neuronal surface that have been implicated in the control of neuroplasticity and memory. Age-related reduction of chondroitin 6-sulphates (C6S) leads to PNNs becoming more inhibitory. Here, we investigated whether manipulation of the chondroitin sulphate (CS) composition of the PNNs could restore neuroplasticity and alleviate memory deficits in aged mice.



tags: #neuroscience #aging #chondroitin #neuroplasticity #6-sulphate #supplements

Chondroitin 6-sulphate is required for neuroplasticity and memory in ageing - Molecular Psychiatry

Perineuronal nets (PNNs) are chondroitin sulphate proteoglycan-containing structures on the neuronal surface that have been implicated in the control of neuroplasticity and memory. Age-related reduction of chondroitin 6-sulphates (C6S) leads to PNNs becoming more inhibitory. Here, we investigated whether manipulation of the chondroitin sulphate (CS) composition of the PNNs could restore neuroplasticity and alleviate memory deficits in aged mice.








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