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Ivermectin Docks to the SARS-CoV-2 Spike Receptor-binding Domain Attached to ACE2Science & Medicine Blogs Jan 18, 2023 by PubMed SARS-CoV-2 viral spike protein binds to the membrane-bound form of angiotensin-converting enzyme 2 (ACE2) to infect the host cell. For this reason, we carried out a docking study to determine if ivermectin might be able to attach to the SARS-CoV-2 spike receptor-binding domain bound with ACE2. [...] The ivermectin docking site we identified, between the viral spike and the ACE2 receptor, may interfere with the attachment of the spike to the human cell membrane. tags: #humans #covid-19 #pneumonia #sars-cov-2 #nih #pubmed-abstract #nlm #ncbi #national-institutes-of-health #national-center-for-biotechnology-information #national-library-of-medicine #medline #pmid-32871846 #pmc7652439 #doi-1021873-invivo12134 #steven-lehrer #peter-h-rheinstein #angiotensin-converting-enzyme-2 #betacoronavirus---chemistry #betacoronavirus---drug-effects* #betacoronavirus---pathogenicity #binding-sites---drug-effects #cell-membrane---drug-effects #coronavirus-infections---drug-therapy* #coronavirus-infections---virology #drug-repositioning #histidine---chemistry #ivermectin---chemistry* #ivermectin---therapeutic-use #leucine---chemistry #molecular-docking-simulation #pandemics #peptidyl-dipeptidase-a---chemistry* #peptidyl-dipeptidase-a---drug-effects #viral---drug-therapy* #viral---virology #streptomyces---chemistry |
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Ivermectin Docks to the SARS-CoV-2 Spike Receptor-binding Domain Attached to ACE2 - PubMed SARS-CoV-2 viral spike protein binds to the membrane-bound form of angiotensin-converting enzyme 2 (ACE2) to infect the host cell. For this reason, we carried out a docking study to determine if ivermectin might be able to attach to the SARS-CoV-2 spike receptor-binding domain bound with ACE2. [...] The ivermectin docking site we identified, between the viral spike and the ACE2 receptor, may interfere with the attachment of the spike to the human cell membrane. | |
