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DeepMind's protein-folding AI has solved a 50-year-old grand challenge of biology

DeepMind has already notched up a streak of wins, showcasing AIs that have learned to play a variety of complex games with superhuman skill, from Go and StarCraft to Atari's entire back catalogue. But Demis Hassabis, DeepMind's public face and co-founder, has always stressed that these successes were just stepping stones towards a larger goal:...

Jan 19, 2021 by MIT Technology Review
Science & Medicine News
Cellular survival over genomic perfection

Damage to DNA occurs continuously. DNA quality control mechanisms, such as DNA repair and replicative pathways, mitigate that damage and preserve the DNA sequence. Mutations are believed to arise when DNA lesions are not repaired appropriately, and they are thought to be an indicator of ineffectual DNA quality control.

Nov 24, 2019 by Science
Science & Medicine Blogs
The next generation of CRISPR-Cas technologies and applications

CRISPR-Cas systems have revolutionized genome editing, and the CRISPR-Cas toolkit has been expanding to include single-base editing enzymes, targeting RNA and fusing inactive Cas proteins to effectors that regulate various nuclear processes. Consequently, CRISPR-Cas systems are being tested for gene and cell therapies.

Jul 04, 2019 by Duke University via Nature
Science & Medicine News
A Completely New Way to Picture DNA in Cells

Just how are things organized in a living cell? What's next to what, in three dimensions? That is, of course, a really hard question to answer, but we're going to have to be able to answer it in a lot of contexts (and at high resolution) if we're ever going to understand what's going on down there.

Jun 29, 2019 by Derek Lowe via Science Translational Medicine
Science & Medicine Blogs
Broad Institute Research Roundup - June 2019

Seeing cells through a DNA lens, bringing new autism genes to the forefront, mining tuberculosis mutants for new treatment options, and more.

Jun 21, 2019 by Broad Institute
Science & Medicine Articles



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